PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease.
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Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brainQuality control systems in cardiac agingMolecular substrates of schizophrenia: homeostatic signaling to connectivityNeuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human AstrocytesMonitoring and optimising cognitive function in cancer patients: Present knowledge and future directions.Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases.Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging.MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal CortexStatus of the Parkinson's disease gene family expression in non-small-cell lung cancer.Protective Effects of Edaravone in Adult Rats with Surgery and Lipopolysaccharide Administration-Induced Cognitive Function Impairment.Rapamycin, Autophagy, and Alzheimer's DiseaseDelayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activityBrain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases.Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging.Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease.Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy.Activation of mTOR: a culprit of Alzheimer's disease?Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration.Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's diseaseCerebral insulin, insulin signaling pathway, and brain angiogenesis.Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation.Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.Hydrogen sulfide-induced processing of the amyloid precursor protein in SH-SY5Y human neuroblastoma cells involves the PI3-K/Akt signaling pathway.Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling.4-hydroxynonenal-mediated signaling and aging.Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer's Disease?Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment.PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy.Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.Oxidative Stress in Stem Cell Aging.Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats.Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease.Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.Effects of piceatannol and pterostilbene against β-amyloid-induced apoptosis on the PI3K/Akt/Bad signaling pathway in PC12 cells.AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain.mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.
P2860
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P2860
PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
PI3-kinase/Akt/mTOR signaling: ...... cline and Alzheimer's disease.
@en
type
label
PI3-kinase/Akt/mTOR signaling: ...... cline and Alzheimer's disease.
@en
prefLabel
PI3-kinase/Akt/mTOR signaling: ...... cline and Alzheimer's disease.
@en
P1476
PI3-kinase/Akt/mTOR signaling: ...... cline and Alzheimer's disease.
@en
P2093
Cora O' Neill
P304
P356
10.1016/J.EXGER.2013.02.025
P577
2013-03-05T00:00:00Z