Obscurins: unassuming giants enter the spotlight. - Wikidata - awgldk - TriplyDB

Obscurins: unassuming giants enter the spotlight.

Obscurins: unassuming giants enter the spotlight.

http://www.wikidata.org/entity/Q38091348

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Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit Obscure functions: the location-function relationship of obscurins.Obscurins: Goliaths and Davids take over non-muscle tissues.Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing Targeted next-generation sequencing detects novel gene-phenotype associations and expands the mutational spectrum in cardiomyopathies.Sternopygus macrurus electric organ transcriptome and cell size exhibit insensitivity to short-term electrical inactivity.Obscurin variants and inherited cardiomyopathies.Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis.

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Obscurins: unassuming giants enter the spotlight.

http://www.wikidata.org/entity/Q38091348

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Obscurins: unassuming giants enter the spotlight.

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Obscurins: unassuming giants enter the spotlight.

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Aikaterini Kontrogianni-Konstantopoulos

http://www.w3.org/2001/XMLSchema#string

Li-Yen R Hu

http://www.w3.org/2001/XMLSchema#string

Maegen A Ackermann

http://www.w3.org/2001/XMLSchema#string

Marey Shriver

http://www.w3.org/2001/XMLSchema#string

Nicole A Perry

http://www.w3.org/2001/XMLSchema#string

P2860

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin

Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum

Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

Obscurin is a ligand for small ankyrin 1 in skeletal muscle

Different obscurin isoforms localize to distinct sites at sarcomeres

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas

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479-486

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scholarly article

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10.1002/IUB.1157

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6

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65

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2013-03-20T00:00:00Z

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23512348

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3957234

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