Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family.
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Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathwaysGetting TRAIL back on track for cancer therapyIntegrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapyAberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activationThe linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL.Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis.TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill.TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation.TRAIL-R2 promotes skeletal metastasis in a breast cancer xenograft mouse model.XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis.Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis.TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors.Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy.Potential Role of TRAIL in Metastasis of Mutant KRAS Expressing Lung AdenocarcinomaGold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cellsThe anti-tumor activity of E1A and its implications in cancer therapy.Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2.TRAIL-based therapy in pediatric bone tumors: how to overcome resistance.Surviving apoptosis: life-death signaling in single cells.Apoptotic and autophagic pathways with relevant small-molecule compounds, in cancer stem cells.Death ligands and granulysin: mechanisms of tumor cell death induction and therapeutic opportunities.MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro.TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models.PKCα-GSK3β-NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis.Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancerUsing natural products to promote caspase-8-dependent cancer cell death.Intracellular localization of DR5 and related regulatory pathways as a mechanism of resistance to TRAIL in cancer.Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cellsDominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexesTrail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes.Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels.TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic "Achilles heel" for the TrkAIII oncoprotein in neuroblastoma.Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells.The dark side of TRAIL signaling.TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.
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Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Non-canonical kinase signaling ...... in the death receptor family.
@en
type
label
Non-canonical kinase signaling ...... in the death receptor family.
@en
prefLabel
Non-canonical kinase signaling ...... in the death receptor family.
@en
P2093
P2860
P356
P1476
Non-canonical kinase signaling ...... in the death receptor family.
@en
P2093
B Weyhenmeyer
F A E Kruyt
G J Peters
P2860
P2888
P304
P356
10.1038/CDD.2013.28
P577
2013-04-12T00:00:00Z
P5875
P6179
1021526067