Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. - Wikidata - awgldk - TriplyDB

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

http://www.wikidata.org/entity/Q38107280

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NAD⁺-Metabolizing Ectoenzymes in Remodeling Tumor-Host Interactions: The Human Myeloma Model Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.Increased plasma nicotinamide phosphoribosyltransferase is associated with a hyperproliferative phenotype and restrains disease progression in MPN-associated myelofibrosis.Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer.Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma.An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma Metabolic mechanisms of epigenetic regulation.EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells.Physiological and pathophysiological roles of NAMPT and NAD metabolism.Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape.Crystal structure-based comparison of two NAMPT inhibitors.Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma.Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles.Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities.Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma.Targeting NAMPT for Therapeutic Intervention in Cancer and Inflammation: Structure-Based Drug Design and Biological Screening.Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin.Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma.Nampt/PBEF/visfatin upregulation in colorectal tumors, mirrored in normal tissue and whole blood of colorectal cancer patients, is associated with metastasis, hypoxia, IL1β, and anemia.Treatment of Cancer with NAMPT Inhibitors.Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes.PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer.Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma.NAD metabolism fuels human and mouse intestinal inflammation.Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status.Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma.Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment.Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement

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P2860

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

http://www.wikidata.org/entity/Q38107280

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article científic

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article scientifique

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Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

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Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

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Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

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Journal of Medicinal Chemistry

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Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

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Alberto Massarotti

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Armando A Genazzani

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Cristina Travelli

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Gian Cesare Tron

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Gohar Fakhfouri

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Reza Rahimian

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Ubaldina Galli

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6279-6296

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scholarly article

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10.1021/JM4001049

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16

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56

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2013-05-31T00:00:00Z

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23679915

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