Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
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Nociceptin and the nociceptin receptor in learning and memoryThe Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled ReceptorA Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.The Nociceptin Receptor as an Emerging Molecular Target for Cocaine AddictionDecreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicidesNociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models.Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala.Cebranopadol : a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors.Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress.Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands.In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403.Functional pharmacological characterization of SER100 in cardiovascular health and disease.Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists.Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness."In silico" study of the binding of two novel antagonists to the nociceptin receptor.Involvement of neurotransmitters in the action of the nociceptin/orphanin FQ peptide-receptor system on passive avoidance learning in rats.Brain mechanisms mediating effects of stress on reward sensitivityNociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic
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P2860
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artículo científico
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name
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
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Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
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prefLabel
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
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P1476
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs
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P2093
Girolamo Calo'
P356
10.1016/J.PHARMTHERA.2013.05.008
P577
2013-05-24T00:00:00Z