In vitro models in the study of structure-activity relationships of narcotic analgesics.
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Dynorphin-(1-13), an extraordinarily potent opioid peptideA brief history of opiates, opioid peptides, and opioid receptorsA study of the role of cyclic adenosine 3',5'-monophosphate in the depression by opiates and opioid peptides of excitatory junction potentials in the mouse vas deferensEnkephalins in large bowel malignancy and in acute appendicitis.Proposal for the biologically active conformation of opiates and enkephalin.Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesicsAssessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey.Potentiation of angiotensin II-induced natriuresis by indomethacin in the rat [proceedings].Inhibition of [3H]-naloxone binding by opiate agonists [proceedings]Comparison of the receptor binding characteristics of opiate agonists interacting with mu- or kappa-receptors.Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions.Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists.Effects of opioids on noncholinergic excitatory responses of the guinea-pig isolated ileum: inhibition of release of enteric substance P.Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig.Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation.Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.Dextrorphan binds to opioid receptors in guinea-pig brain membranes and is an antagonist at opioid receptors in myenteric plexus.A history of intraspinal analgesia, a small and personal journey.Spinal opioid bioavailability in postoperative pain.The assay of the agonist activities of N-methyl- and N-nor-homologues of morphine derivatives by the guinea-pig ileum method.The opiate receptors and the discovery of opioid-like peptides.The next frontier in the molecular biology of the opioid system. The opioid receptors.Inhibition of neuronal firing by opiates: evidence against the involvement of cyclic nucleotides.Endogenous opiates and the digestive system.Opiate-like analgesic activity in general anaesthetics.Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats.The opiate receptor and opoid peptides.The mechanism of action of narcotic analgesics in the guinea-pig ileum.Quantum chemical studies of molecular features and receptor interactions that modulate opiate agonist and antagonist activity.Narcotic agonist and antagonist potencies of a homologous series of N-alkyl-norketobemidones measured by the guinea-pig ileum and mouse vas deferens methods.Agonist and antagonist potencies of isomeric 2,3-dimethyl-3-aryl-piperidines.Structural requirements in the reaction of morphine uridine diphosphate glucuronyltransferase with opioid substances.Opioid inhibition of synaptic transmission in the guinea-pig myenteric plexus.Manifestations of acute opiate withdrawal contracture in rabbit jejunum after mu-, kappa- and delta-receptor agonist exposure.Effects of endorphins on different parts of the gastrointestinal tract of rat and guinea-pig in vitro.In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential.Kinetics of morphine-sensitive [3H]-acetylcholine release from the guinea-pig myenteric plexus.Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones.
P2860
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P2860
In vitro models in the study of structure-activity relationships of narcotic analgesics.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
In vitro models in the study of structure-activity relationships of narcotic analgesics.
@en
type
label
In vitro models in the study of structure-activity relationships of narcotic analgesics.
@en
prefLabel
In vitro models in the study of structure-activity relationships of narcotic analgesics.
@en
P1476
In vitro models in the study of structure-activity relationships of narcotic analgesics.
@en
P2093
Kosterlitz HW
Waterfield AA
P356
10.1146/ANNUREV.PA.15.040175.000333
P577
1975-01-01T00:00:00Z