Sulfoximines: a neglected opportunity in medicinal chemistry.
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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary DiseasesEnantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transferFluorinated sulfoximines: syntheses, properties and applications.Sulfur imidations: access to sulfimides and sulfoximines.Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification.Synthesis of a Sulfonimidamide-Based Analog of Tasisulam and Its Biological Evaluation in the Melanoma Cell Lines SKMel23 and A375.Sulfoximine substituted quinazolines for pharmaceutical compositions US 20150005278 (A1): a patent evaluation.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Sulfonimidamides in Medicinal and Agricultural Chemistry.Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates.Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides.A New, Practical One-Pot Synthesis of Unprotected Sulfonimidamides by Transfer of Electrophilic NH to Sulfinamides.Iron-catalyzed imidative kinetic resolution of racemic sulfoxides.Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.Palladium/Copper-Cocatalyzed Oxidative Amidobrominations of Alkenes.Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.Copper-Catalyzed Direct Sulfoximination of Heteroaromatic N-Oxides by Dual C-H/N-H Dehydrogenative Cross-Coupling.Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines.Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.Iron(II)-Catalyzed Direct Synthesis of NH Sulfoximines from Sulfoxides.Dibenzothiophene Sulfoximine as an NH3 Surrogate in the Synthesis of Primary Amines by Copper-Catalyzed C-X and C-H Bond Amination.Synthesis of N-Propargylsulfoximines by Copper-Catalyzed A3 -Couplings.SuFEx Chemistry of Thionyl Tetrafluoride (SOF4 ) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates.Mechanistic investigation of the NH-sulfoximination of sulfide. Evidence for λ6-sulfanenitrile intermediates.Access to N-cyanosulfoximines by transition metal-free iminations of sulfoxides.Sulfur-Containing Agrochemicals.Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins.Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions.Studies toward understanding the SAR around the sulfoximine moiety of the sap-feeding insecticide sulfoxaflor.A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles.1,2-Thiazines: One-Pot Syntheses Utilizing Mono and Diaza Analogs of Sulfones.The N-silylation of sulfoximines.Copper-catalyzed N-methylation/ethylation of sulfoximines.Transition metal-free aroylation of NH-sulfoximines with methyl arenes.Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N-Functionalized Tertiary Sulfonimidamides.Copper-Catalyzed S-C/S-N Bond Interconversions.Iron(II)-Catalyzed Direct Synthesis of NH Sulfoximines from SulfoxidesDibenzothiophene Sulfoximine as an NH3 Surrogate in the Synthesis of Primary Amines by Copper-Catalyzed C−X and C−H Bond AminationSynthesis of Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents and Their Use in Transition-Metal-Free Sulfoximidations of Alkynes
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P2860
Sulfoximines: a neglected opportunity in medicinal chemistry.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Sulfoximines: a neglected opportunity in medicinal chemistry.
@en
type
label
Sulfoximines: a neglected opportunity in medicinal chemistry.
@en
prefLabel
Sulfoximines: a neglected opportunity in medicinal chemistry.
@en
P2860
P356
P1476
Sulfoximines: a neglected opportunity in medicinal chemistry.
@en
P2093
Ulrich Lücking
P2860
P304
P356
10.1002/ANIE.201302209
P407
P577
2013-08-09T00:00:00Z