Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy. - Wikidata - awgldk - TriplyDB

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy.

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy.

http://www.wikidata.org/entity/Q38132274

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Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma CrossHub: a tool for multi-way analysis of The Cancer Genome Atlas (TCGA) in the context of gene expression regulation mechanisms Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysis.Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.Mitochondrial and postmitochondrial survival signaling in cancer.Mitochondrial VDAC1-based peptides: Attacking oncogenic properties in glioblastoma.Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis.Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection Regulation of VDAC trafficking modulates cell death.Important molecular genetic markers of colorectal cancer.Metabolic enzymes: key modulators of functionality in cancer stem-like cells.Targeting cancer cell mitochondria as a therapeutic approach: recent updates.Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway.The PI3K pathway in B cell metabolism Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.Viral E6/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines.Upregulation of NETO2 gene in colorectal cancer.Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development.Selective Induction of Cancer Cell Death by VDAC1-based Peptides and their Potential Use in Cancer Therapy.FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells.Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer.HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer.Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR).

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Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy.

http://www.wikidata.org/entity/Q38132274

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Targeting VDAC-bound hexokinas ...... ncomitant anti-cancer therapy.

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Targeting VDAC-bound hexokinas ...... ncomitant anti-cancer therapy.

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Targeting VDAC-bound hexokinas ...... ncomitant anti-cancer therapy.

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14728222.2013.833607

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Expert Opinion on Therapeutic Targets

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Targeting VDAC-bound hexokinas ...... ncomitant anti-cancer therapy.

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Alexander A Kirpiy

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Alexey A Dmitriev

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Anna V Kudryavtseva

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George S Krasnov

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Valentina A Lakunina

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase

ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

Subcellular dynamics of multifunctional protein regulation: mechanisms of GAPDH intracellular translocation

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

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10.1517/14728222.2013.833607

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