Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters.
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Systems Biology Approaches to Understand Natural Products BiosynthesisChassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolismLessons learned from the transformation of natural product discovery to a genome-driven endeavorMetabolomics investigation of recombinant mTNFα production in Streptomyces lividans.Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivativesDNA assembly techniques for next-generation combinatorial biosynthesis of natural products.Terpene synthases are widely distributed in bacteria.Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system.Systematic unravelling of the biosynthesis of poly (L-diaminopropionic acid) in Streptomyces albulus PD-1.New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives.Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenalGenetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439.Genetic regulation and manipulation for natural product discovery.Engineering microbial hosts for production of bacterial natural productsActivation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.Challenges in the Heterologous Production of Antibiotics in Streptomyces.Molecular beacons to identify gifted microbes for genome mining.Natural products discovery from micro-organisms in the post-genome era.Endophytic actinobacteria: Diversity, secondary metabolism and mechanisms to unsilence biosynthetic gene clusters.A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes.Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology.Adaptive Evolution of Extreme Acidophile Sulfobacillus thermosulfidooxidans Potentially Driven by Horizontal Gene Transfer and Gene Loss.Blockage of the early step of lankacidin biosynthesis caused a large production of pentamycin, citreodiol and epi-citreodiol in Streptomyces rochei.Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.Antimicrobial potential and taxonomic investigation of piezotolerant Streptomyces sp. NIOT-Ch-40 isolated from deep-sea sediment.Interrogation of Streptomyces avermitilis for efficient production of avermectins.Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester.Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis.Establishing a high yielding streptomyces-based cell-free protein synthesis system.Gifted microbes for genome mining and natural product discovery.MbtH homology codes to identify gifted microbes for genome mining.High production of a class III lantipeptide AmfS in Streptomyces griseus.Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.
P2860
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P2860
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Genome mining of the Streptomy ...... of biosynthetic gene clusters.
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type
label
Genome mining of the Streptomy ...... of biosynthetic gene clusters.
@en
prefLabel
Genome mining of the Streptomy ...... of biosynthetic gene clusters.
@en
P2093
P2860
P1476
Genome mining of the Streptomy ...... of biosynthetic gene clusters.
@en
P2093
Haruo Ikeda
Satoshi Omura
Shin-ya Kazuo
P2860
P304
P356
10.1007/S10295-013-1327-X
P577
2013-08-29T00:00:00Z