Targeting lactate metabolism for cancer therapeutics. - Wikidata - awgldk - TriplyDB

Targeting lactate metabolism for cancer therapeutics.

Targeting lactate metabolism for cancer therapeutics.

http://www.wikidata.org/entity/Q38133722

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Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction Role of multifaceted regulators in cancer glucose metabolism and their clinical significance Glucose metabolism in gastric cancer: The cutting-edge Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity Targeted Therapies in Adult B-Cell Malignancies Progress toward overcoming hypoxia-induced resistance to solid tumor therapy Molecular pathways: trafficking of metabolic resources in the tumor microenvironment Redox control of glutamine utilization in cancer Novel therapeutic targets of tumor metabolism Heterogeneity of glycolysis in cancers and therapeutic opportunities.Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate Reexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect ROS homeostasis and metabolism: a critical liaison for cancer therapy Evidence of cancer-promoting roles for AMPK and related kinases Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines Droplet Microfluidic Platform for the Determination of Single-Cell Lactate Release.A Pilot Proteogenomic Study with Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung Adenocarcinoma Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo A Biomarker for LDH Activity MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.Targeting MYC Dependence by Metabolic Inhibitors in Cancer Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma.Cancer heterogeneity is not compatible with one unique cancer cell metabolic map MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.Glycolytic reliance promotes anabolism in photoreceptors.Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?Fibroblast heterogeneity in the cancer wound.Restricting carbohydrates to fight head and neck cancer-is this realistic?Attacking the supply wagons to starve cancer cells to death.Organization of enzyme concentration across the metabolic network in cancer cells LUD, a new protein domain associated with lactate utilization.Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma.Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain.Acidic microenvironment and bone pain in cancer-colonized bone Metabolic Signatures of Human Breast Cancer.

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P2860

Targeting lactate metabolism for cancer therapeutics.

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artikel ilmiah

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Targeting lactate metabolism for cancer therapeutics.

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Targeting lactate metabolism for cancer therapeutics.

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Journal of Clinical Investigation

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Targeting lactate metabolism for cancer therapeutics.

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Joanne R Doherty

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John L Cleveland

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P2860

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator)

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency

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10.1172/JCI69741

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9

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2013-09-03T00:00:00Z

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