AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
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PI3K and AKT: Unfaithful Partners in CancerCharacterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinaseSGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers.Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma.mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity.Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell linesSGK3 (CISK) may induce tumor angiogenesis (Hypothesis).Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA PathwayInactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cellsTsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.Wharton's Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro.INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growthPost-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complexThe mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma.INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling.LncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis
P2860
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P2860
AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
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article científic
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AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
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type
label
AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
@en
prefLabel
AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
@en
P2860
P356
P1476
AKT-independent PI3-K signaling in cancer - emerging role for SGK3
@en
P2093
Karen E Sheppard
Maressa A Bruhn
P2860
P304
P356
10.2147/CMAR.S35178
P407
P577
2013-08-26T00:00:00Z