Therapeutic strategies impacting cancer cell glutamine metabolism. - Wikidata - awgldk - TriplyDB

Therapeutic strategies impacting cancer cell glutamine metabolism.

Therapeutic strategies impacting cancer cell glutamine metabolism.

http://www.wikidata.org/entity/Q38139096

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Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition Mitochondrial sirtuins and their relationships with metabolic disease and cancer.Synthesis and antiproliferative activity of glutamic acid-based dipeptides.Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.Effects of deranged metabolism on epigenetic changes in cancer.The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.Drug-induced amino acid deprivation as strategy for cancer therapy.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Glutaminase GLS1 Inhibitors as Potential Cancer Treatment.Targeting amino acid metabolism for cancer therapy.T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer.Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies.Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth.Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.Glutamate enrichment as new diagnostic opportunity in breast cancer.An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models

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Therapeutic strategies impacting cancer cell glutamine metabolism.

http://www.wikidata.org/entity/Q38139096

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2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

@wuu

2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

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2013年學術文章

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name

Therapeutic strategies impacting cancer cell glutamine metabolism.

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Therapeutic strategies impacting cancer cell glutamine metabolism.

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Therapeutic strategies impacting cancer cell glutamine metabolism.

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Future Medicinal Chemistry

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Therapeutic strategies impacting cancer cell glutamine metabolism.

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Kristin F Wilson

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Michael J Lukey

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Richard A Cerione

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P2860

Targeting aspartate aminotransferase in breast cancer

Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

Full-length human glutaminase in complex with an allosteric inhibitor

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth

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10.4155/FMC.13.130

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14

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