Ten years of dengue drug discovery: progress and prospects.
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Zika virus: History, emergence, biology, and prospects for controlPotent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingFlaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral interventionFluorescence anisotropy (polarization): from drug screening to precision medicine.Dengue: Moving from Current Standard of Care to State-of-the-Art TreatmentZika virus: An emergent neuropathological agentA crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replicationStructure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virusAnti-dengue drug: viral polyprotein, a potential targetGenomic approaches for understanding dengue: insights from the virus, vector, and hostDengue: an update on treatment optionsEmerging Zika Virus Infection: A Rapidly Evolving SituationPurification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitorsThe interface between methyltransferase and polymerase of NS5 is essential for flavivirus replicationDengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directionsNovel Broad Spectrum Inhibitors Targeting the Flavivirus MethyltransferaseCissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus SerotypesAntiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infectionsIdentification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virusCyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agentsInhibitors compounds of the flavivirus replication processDengue Virus Non-Structural Protein 5A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.Therapeutic Potential of Spirooxindoles as Antiviral AgentsBaicalin, a metabolite of baicalein with antiviral activity against dengue virus.Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans.C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection.Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patientsA small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture.Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope.Mapping the Interactions between the NS4B and NS3 proteins of dengue virusThe burden of dengue and chikungunya worldwide: implications for the southern United States and CaliforniaDiscovery of Dengue Virus NS4B Inhibitors.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA PolymeraseIdentification of covalent active site inhibitors of dengue virus protease.Dengue Vaccines: A Perspective from the Point of View of Intellectual Property.
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P2860
Ten years of dengue drug discovery: progress and prospects.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Ten years of dengue drug discovery: progress and prospects.
@en
type
label
Ten years of dengue drug discovery: progress and prospects.
@en
prefLabel
Ten years of dengue drug discovery: progress and prospects.
@en
P2093
P1433
P1476
Ten years of dengue drug discovery: progress and prospects.
@en
P2093
Christian G Noble
David Beer
Fumiaki Yokokawa
Hongping Dong
Julien Lescar
Paul Smith
Qing-Yin Wang
Shahul Nilar
Yen-Liang Chen
P304
P356
10.1016/J.ANTIVIRAL.2013.09.013
P577
2013-09-27T00:00:00Z