Quinolinic acid: an endogenous neurotoxin with multiple targets.
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Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple SclerosisKynurenine 3-Monooxygenase: An Influential Mediator of NeuropathologyToxin-Induced Experimental Models of Learning and Memory ImpairmentQuinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticityNeurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation.Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration.Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenalMechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegansTargeted plasma metabolome response to variations in dietary glycemic load in a randomized, controlled, crossover feeding trial in healthy adultsPreferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities.Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid ProductionCannabinoids: Glutamatergic Transmission and Kynurenines.Cytoskeleton as a Target of Quinolinic Acid Neurotoxicity: Insight from Animal Models.Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper.Oxidative Stress, Disrupted Energy Metabolism, and Altered Signaling Pathways in Glutaryl-CoA Dehydrogenase Knockout Mice: Potential Implications of Quinolinic Acid Toxicity in the Neuropathology of Glutaric Acidemia Type I.Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent RetinaDrugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior.Quinolinic acid induces cell apoptosis in PC12 cells through HIF-1-dependent RTP801 activation.Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning.Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer's Disease.Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment.Suppression of Tryptophan 2,3-Dioxygenase Produces a Slow Heartbeat Phenotype in Drosophila melanogaster.LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium.Kynurenine Pathway Metabolites in Alzheimer's Disease.Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.Teasing apart NAD+ metabolism in inflammation: commentary on Zhou et al. (2016). Br J Pharmacol 173: 2352-2368.An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases.
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P2860
Quinolinic acid: an endogenous neurotoxin with multiple targets.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Quinolinic acid: an endogenous neurotoxin with multiple targets.
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type
label
Quinolinic acid: an endogenous neurotoxin with multiple targets.
@en
prefLabel
Quinolinic acid: an endogenous neurotoxin with multiple targets.
@en
P2093
P2860
P356
P1476
Quinolinic acid: an endogenous neurotoxin with multiple targets.
@en
P2093
Benjamin Pineda
Camilo Ríos
José Pedraza-Chaverrí
Perla Ugalde Muñiz
Rafael Lugo-Huitrón
Verónica Pérez-de la Cruz
P2860
P304
P356
10.1155/2013/104024
P577
2013-09-05T00:00:00Z