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The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivoImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationExtracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammationAkirin2 is essential for the formation of the cerebral cortexFrontotemporal Dementia.TMEM106B expression is reduced in Alzheimer's disease brainsInitial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.PABPN1 suppresses TDP-43 toxicity in ALS disease models.USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian ClockMass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral SclerosisChanges in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration.Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRPEarly Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.Compromised MAPK signaling in human diseases: an update.Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates.TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.TDP-43 in the spectrum of MND-FTLD pathologies.Autoantibodies against TYMS and PDLIM1 proteins detected as circulatory signatures in Indian breast cancer patients.Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches.TDP-43 regulates cancer-associated microRNAs.LINE-1 Retrotransposons in Healthy and Diseased Human Brain.Genetic analysis of patients with familial and sporadic amyotrophic lateral sclerosis in a Brazilian Research Center.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target CellsTranscriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The role of TDP-43 in the pathogenesis of ALS and FTLD.
@en
type
label
The role of TDP-43 in the pathogenesis of ALS and FTLD.
@en
prefLabel
The role of TDP-43 in the pathogenesis of ALS and FTLD.
@en
P356
P1476
The role of TDP-43 in the pathogenesis of ALS and FTLD.
@en
P2093
Francisco E Baralle
Marco Baralle
P304
P356
10.1042/BST20130186
P577
2013-12-01T00:00:00Z