Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.

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http://www.wikidata.org/entity/Q38170468
Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsTransgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicityAssessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology.Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis.Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver.Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.Humanized organs in gene-edited animals.Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
P2860

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.

Item
http://www.wikidata.org/entity/Q38170468
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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artigo científico
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Current status of prediction o ...... ric mice with humanized liver.
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Current status of prediction o ...... ric mice with humanized liver.
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Current status of prediction o ...... ric mice with humanized liver.
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P1433
P1476
P2093
P2860
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Current status of prediction o ...... ric mice with humanized liver.
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P2093
P2860
P304
P31
P356
10.3109/00498254.2013.868062
P407
P433
P478
P577
P698