Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery.
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Recent advances in trifluoromethylation reactions with electrophilic trifluoromethylating reagents.Recent progress in direct introduction of fluorinated groups on alkenes and alkynes by means of C-H bond functionalization.Recent Progress Toward the Synthesis of Trifluoromethyl- and Difluoromethyl-Substituted Cyclopropanes.Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents.Mechanistic studies on intramolecular C-H trifluoromethoxylation of (hetero)arenes via OCF3-migration.Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines.Selective C-O bond formation via a photocatalytic radical coupling strategy: access to perfluoroalkoxylated (ORF) arenes and heteroarenes.Synthesis of Trifluoromethoxylated (Hetero)Arenes via OCF3 Migration.Synthesis of Ethers via Reaction of Carbanions and Monoperoxyacetals.Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers.Direct Dehydroxytrifluoromethoxylation of Alcohols.Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids.Direct Monofluoromethylthiolation with S-(Fluoromethyl) Benzenesulfonothioate.Synthesis of Trifluoromethylthiolated Alkenes and Ketones by Decarboxylative Functionalization of Cinnamic Acids.C-H Xanthylation: A Synthetic Platform for Alkane Functionalization.Asymmetric silver-catalysed intermolecular bromotrifluoromethoxylation of alkenes with a new trifluoromethoxylation reagent.Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides.Selenide-Catalyzed Stereoselective Construction of Tetrasubstituted Trifluoromethylthiolated Alkenes with Alkynes.Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines.Silver-mediated direct trifluoromethoxylation of α-diazo esters via the (-)OCF3 anion.Enantioselective Trifluoromethylthiolating Lactonization Catalyzed by an Indane-Based Chiral Sulfide.Regioselective Synthesis of N-Heteroaromatic Trifluoromethoxy Compounds by Direct O-CF3 Bond Formation.Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers.A General Strategy for Aliphatic C-H Functionalization Enabled by Organic Photoredox Catalysis.Trifluoromethoxylation of arenes: synthesis of ortho-trifluoromethoxylated aniline derivatives by OCF3 migration.Cp*CoIII-catalyzed directed C-H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines.(18)F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [(18)F]Fluoride.Evaluation of Efficient and Practical Methods for the Preparation of Functionalized Aliphatic Trifluoromethyl Ethers.PhSO2 SCF2 H: A Shelf-Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation.Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp(2) ) and C(sp) Centers.Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives.Copper-Mediated [(Diethylphosphono)difluoromethyl]thiolation of α-Bromo KetonesPalladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond FunctionalizationCopper-Catalyzed Innate Ethoxycarbonyldifluoromethylation of Electron-Rich ArenesCopper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer ApproachDirect Vicinal Difunctionalization of Alkynes: An Efficient Approach Towards the Synthesis of Highly Functionalized Fluorinated Alkenes
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P2860
Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Trifluoromethyl ethers and -th ...... chemistry and drug discovery.
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type
label
Trifluoromethyl ethers and -th ...... chemistry and drug discovery.
@en
prefLabel
Trifluoromethyl ethers and -th ...... chemistry and drug discovery.
@en
P2093
P50
P1476
Trifluoromethyl ethers and -th ...... l chemistry and drug discovery
@en
P2093
Armen Panossian
Frederic R Leroux
Gregory Landelle
P304
P356
10.2174/1568026614666140202210016
P577
2014-01-01T00:00:00Z