Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes.
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Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β.Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders.Molecular recognition in chemical and biological systems.Personalized Medicine and Resurrected Hopes for the Management of Alzheimer's Disease: A Modular Approach Based on GSK-3β Inhibitors.Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease.The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia.The Multimerization State of the Amyloid-β42 Amyloid Peptide Governs its Interaction Network with the Extracellular Matrix.The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats.Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin.Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling.Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group.Construction, Enzyme Response, and Substrate Capacity of a Hyaluronan-Cyclodextrin Supramolecular Assembly.Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivativesBioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer's disease.Optimized curcumin formulations for the treatment of Alzheimer's disease: A patent evaluation.Synthesis of Novel Oxazolo[4,5-b]pyridine-2-one based 1,2,3-triazoles as Glycogen Synthase Kinase-3β Inhibitors with Anti-inflammatory Potential.Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.
P2860
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P2860
Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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Alzheimer's disease, enzyme ta ...... l products to drug prototypes.
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type
label
Alzheimer's disease, enzyme ta ...... l products to drug prototypes.
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prefLabel
Alzheimer's disease, enzyme ta ...... l products to drug prototypes.
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P50
P1476
Alzheimer's disease, enzyme ta ...... l products to drug prototypes.
@en
P304
P356
10.1016/J.ARR.2014.03.008
P577
2014-04-13T00:00:00Z