Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
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Medical implications of technical accuracy in genome sequencingTherapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryTRPM3 in temperature sensing and beyondOmega pore, an alternative ion channel permeation pathway involved in the development of several channelopathiesMolecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channelsTheoretical and simulation studies on voltage-gated sodium channelsA recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.Elevated resting H(+) current in the R1239H type 1 Hypokalemic Periodic Paralysis mutated Ca(2+) channel.Identification of State-Dependent Blockers for Voltage-Gated Calcium Channels Using a FLIPR-Based Assay.Cellular and Molecular Targets of Menthol ActionsGating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy.Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents.Na leak with gating pore properties in hypokalemic periodic paralysis V876E mutant muscle Ca channel.Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels.Mapping allosteric linkage to channel gating of extracellular domains in the human epithelial sodium channel.When muscle Ca2+ channels carry monovalent cations through gating pores: insights into the pathophysiology of type 1 hypokalaemic periodic paralysis.A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating PoresA leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy
P2860
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P2860
Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
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Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
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prefLabel
Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
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P2860
P356
P1476
Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
@en
P2093
Mohamed Chahine
Pascal Gosselin-Badaroudine
P2860
P356
10.3389/FPHAR.2014.00053
P577
2014-04-03T00:00:00Z