Discovery and preclinical development of vismodegib. - Wikidata - awgldk - TriplyDB

Discovery and preclinical development of vismodegib.

Discovery and preclinical development of vismodegib.

http://www.wikidata.org/entity/Q38214255

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Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target.Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma.Current landscape for treatment of advanced basal cell carcinoma.Multimodality management of high-risk head and neck basal cell carcinoma requiring free-flap reconstruction.The safety and efficacy of sonidegib for the treatment of locally advanced basal cell carcinoma.Role of Vismodegib in the Management of Advanced Periocular Basal Cell Carcinoma.Improved therapy for neuroblastoma using a combination approach: superior efficacy with vismodegib and topotecan Sonic Hedgehog in SCLC.A highlight on Sonic hedgehog pathway.A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor

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Discovery and preclinical development of vismodegib.

http://www.wikidata.org/entity/Q38214255

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artigo científico

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artikel ilmiah

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artículo científico

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Discovery and preclinical development of vismodegib.

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Discovery and preclinical development of vismodegib.

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Discovery and preclinical development of vismodegib.

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17460441.2014.920816

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Expert Opinion on Drug Discovery

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Discovery and preclinical development of vismodegib.

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Daniel P Sutherlin

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Frederic J de Sauvage

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Harvey Wong

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James C Marsters

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Jennifer A Low

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Kirk Robarge

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Lee L Rubin

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Robert L Yauch

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Activating Smoothened mutations in sporadic basal-cell carcinoma

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Small molecule modulation of Smoothened activity

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

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969-984

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scholarly article

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10.1517/17460441.2014.920816

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8

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9

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Stephen E. Gould

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2014-05-23T00:00:00Z

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24857041

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