Tankyrases: structure, function and therapeutic implications in cancer.
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Readers of poly(ADP-ribose): designed to be fit for purposeChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineTankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt SignalingFormation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.A case of fatal Type I congenital disorders of glycosylation (CDG I) associated with low dehydrodolichol diphosphate synthase (DHDDS) activityThe Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutationsProximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cellsWNT signaling - lung cancer is no exception.Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues.Structural insights into SAM domain-mediated tankyrase oligomerization.Exclusive destruction of mitotic spindles in human cancer cells.Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.Specificity of reversible ADP-ribosylation and regulation of cellular processes.WNT signalling in prostate cancer.2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology.Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
P2860
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P2860
Tankyrases: structure, function and therapeutic implications in cancer.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Tankyrases: structure, function and therapeutic implications in cancer.
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type
label
Tankyrases: structure, function and therapeutic implications in cancer.
@en
prefLabel
Tankyrases: structure, function and therapeutic implications in cancer.
@en
P2860
P1476
Tankyrases: structure, function and therapeutic implications in cancer.
@en
P2093
Stefan Krauss
Teemu Haikarainen
P2860
P304
P356
10.2174/1381612820666140630101525
P50
P5008
P577
2014-01-01T00:00:00Z