Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals.
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Opportunities and challenges for direct C-H functionalization of piperazinesScalable C-H Oxidation with Copper: Synthesis of PolyoxypregnanesNickel-catalyzed enantioselective arylation of pyridineDiversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interactionFrom Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape AnalysisPhotoredox Catalysis in Organic ChemistryRing-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.Nickel-catalysed Suzuki-Miyaura coupling of amides.Generation and regioselective trapping of a 3,4-piperidyne for the synthesis of functionalized heterocycles.Synthesis of High-Load, Hybrid Silica-Immobilized Heterocyclic Benzyl Phosphate (Si-OHBP) and Triazolyl Phosphate (Si-OHTP) Alkylating ReagentsSynthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategyDevelopment of a Terpenoid Alkaloid-like Compound Library Based on the Humulene Skeleton.Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine.Diastereoselective Oxidative C-N/C-O and C-N/C-N Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N-Arylindolines.From synthesis to function via iterative assembly of N-methyliminodiacetic acid boronate building blocks.In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides.Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible LightPalladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols.Expedient Access to 2,3-Dihydropyridines from Unsaturated Oximes by Rh(III)-Catalyzed C-H Activation.Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.Late Stage Azidation of Complex Molecules.Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.Synthesis and Utility of Dihydropyridine Boronic Esters.Synthesis of Spirocyclic Indolenines.Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d]pyrimidine Derivatives Containing Electrophilic Warheads.Natural product driven diversity via skeletal remodeling of caryophyllene β-lactam.Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.Macrolactam analogues of macrolide natural products.Systematic investigation of DFT-GIAO 15N NMR chemical shift prediction using B3LYP/cc-pVDZ: application to studies of regioisomers, tautomers, protonation states and N-oxides.Triiodide-Mediated δ-Amination of Secondary C-H Bonds.Platinum-Catalyzed, Terminal-Selective C(sp(3))-H Oxidation of Aliphatic Amines.Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolitesO,N,B-Containing eight-membered heterocycles by ring expansion of boroles with nitrones.Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles.The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination.Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides.Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles.Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides.Palladium-Catalyzed Directed C(sp(3))-H Arylation of Saturated Heterocycles at C-3 Using a Concise Optimization ApproachRemote Oxidation of Aliphatic C-H Bonds in Nitrogen-Containing Molecules.
P2860
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P2860
Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Analysis of the structural div ...... FDA approved pharmaceuticals.
@en
type
label
Analysis of the structural div ...... FDA approved pharmaceuticals.
@en
prefLabel
Analysis of the structural div ...... FDA approved pharmaceuticals.
@en
P356
P1476
Analysis of the structural div ...... FDA approved pharmaceuticals.
@en
P2093
David T Smith
Jon T Njardarson
P304
10257-10274
P356
10.1021/JM501100B
P407
P50
P577
2014-10-07T00:00:00Z