Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.
about
Out of balance: R-loops in human diseaseChtop is a component of the dynamic TREX mRNA export complexReplication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stabilityMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeThe THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningR-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I.Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiaeThe DEAD-box RNA helicase Dbp2 connects RNA quality control with repression of aberrant transcription.The role of TREX in gene expression and diseaseThe THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogrammingProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatinRecruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase IIThe Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mousePIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.Mechanisms of genome instability induced by RNA-processing defects.Replication fork reversal after replication-transcription collision.Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chipGenome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondriaRescue from replication stress during mitosis.The Thoc1 ribonucleoprotein and prostate cancer progression.Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy.Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1pThe Yin and Yang of R-loop biology.Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation.Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere ShorteningTranscription as a source of genome instability.Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity.Replication-transcription conflicts in bacteria.Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stressTranscription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals.The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestineMutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.To the pore and through the pore: a story of mRNA export kinetics.Telomeres and disease: enter TERRA.Impediments to replication fork movement: stabilisation, reactivation and genome instability.
P2860
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P2860
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Genome-wide function of THO/TR ...... pendent replication obstacles.
@en
type
label
Genome-wide function of THO/TR ...... pendent replication obstacles.
@en
prefLabel
Genome-wide function of THO/TR ...... pendent replication obstacles.
@en
P2860
P50
P356
P1433
P1476
Genome-wide function of THO/TR ...... pendent replication obstacles.
@en
P2093
Antonio Marín
Belén Gómez-González
P2860
P304
P356
10.1038/EMBOJ.2011.206
P407
P577
2011-06-24T00:00:00Z