about
Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationIsothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's DiseaseA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyAntitumor activity of SAHA, a novel histone deacetylase inhibitor, against murine B cell lymphoma A20 cells in vitro and in vivo.Manipulating autophagic processes in autoimmune diseases: a special focus on modulating chaperone-mediated autophagy, an emerging therapeutic target.Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutaseA strategy for dissecting the architectures of native macromolecular assembliesImproved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration.Targeting the unfolded protein response for disease intervention.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Molecular and biological hallmarks of ageing.Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport.The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing.Melatonin regulates the autophagic flux via activation of alpha-7 nicotinic acetylcholine receptors.Small molecules as therapeutic agents for inborn errors of metabolism.Proteostasis and Diseases of the Motor Unit.Endoplasmic reticulum proteostasis impairment in agingThe Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic SignificanceRegulation of autophagic flux by CHIP.Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease.A thiol probe for measuring unfolded protein load and proteostasis in cells.Oxidized low-density lipoprotein induced mouse hippocampal HT-22 cell damage via promoting the shift from autophagy to apoptosis.Proteostasis disturbance in amyotrophic lateral sclerosis.Mitophagy in Parkinson's Disease: Pathogenic and Therapeutic Implications.Autophagy manages disease-associated stress granulesReduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention of Mitochondrial Dysfunction After Subarachnoid Hemorrhage.Bioactivity of Olive Oil Phenols in Neuroprotection.Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.Tauopathies: Mechanisms and Therapeutic Strategies.NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.Unraveling the role of motoneuron autophagy in ALS.Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions.Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.Circulating microRNAs in Neurodegenerative Diseases.Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.Lithium limits trimethyltin-induced cytotoxicity and proinflammatory response in microglia without affecting the concurrent autophagy impairment.
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Targeting autophagy in neurodegenerative diseases.
@en
type
label
Targeting autophagy in neurodegenerative diseases.
@en
prefLabel
Targeting autophagy in neurodegenerative diseases.
@en
P2093
P1476
Targeting autophagy in neurodegenerative diseases.
@en
P2093
Claudio Hetz
Leslie Bargsted
René L Vidal
Soledad Matus
P304
P356
10.1016/J.TIPS.2014.09.002
P577
2014-09-27T00:00:00Z