The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.
about
Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1Effects of portulacerebroside a on apoptosis of human leukemia HL60 cells and p38/JNK signaling pathwayTargeting mTOR for the treatment of B cell malignancies.From Waldenström's macroglobulinemia to aggressive diffuse large B-cell lymphoma: a whole-exome analysis of abnormalities leading to transformation.Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia.Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity.A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia.Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.PIM Kinase as an Executional Target in Cancer
P2860
Q33798463-42760267-97B2-44A4-B690-302C3D6B1BFEQ36464303-D2BE3034-EF41-4662-9183-2864580E4C8AQ38709825-53F4BA93-22B0-4D7E-B1FB-1B08817978D6Q41177165-916C430E-85C8-46AC-8EE9-93B17C75CFB6Q42380771-F6DBE784-3912-40B6-9A40-E13D31F0B2F7Q47554666-4511BBF8-6846-4C65-AF52-818C11BD54B8Q52571251-5C26F583-E598-43AC-A148-711FD1D685F8Q55496770-C28008F3-3488-4E97-8F0B-DAD2B287873BQ58128483-B3E19D0A-9596-4D58-BD8C-1025F3727FA3
P2860
The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
The novel combination of dual ...... a via HSF pathway suppression.
@en
type
label
The novel combination of dual ...... a via HSF pathway suppression.
@en
prefLabel
The novel combination of dual ...... a via HSF pathway suppression.
@en
P2093
P2860
P356
P1433
P1476
The novel combination of dual ...... a via HSF pathway suppression.
@en
P2093
Dirim Arslan
Hiromichi Matsushita
Juliana Benito
Kensuke Kojima
Leonidas Platanias
Masako Harada
Rodrigo Jacamo
Saiko Kazuno
Santiago Ramirez
Shinichi Yamamoto
P2860
P304
37930-37947
P356
10.18632/ONCOTARGET.6122
P407
P577
2015-10-14T00:00:00Z