The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. - Wikidata - awgldk - TriplyDB

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

http://www.wikidata.org/entity/Q38279572

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Untangling the Manganese-α-Synuclein Web "Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies"Manganese-induced Neurotoxicity: From C. elegans to Humans From the Cover: Manganese Stimulates Mitochondrial H2O2 Production in SH-SY5Y Human Neuroblastoma Cells Over Physiologic as well as Toxicologic Range Disease-toxicant interactions in Parkinson's disease neuropathology Neurochemistry of lead and manganese Genetic factors and manganese-induced neurotoxicity.Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.Imaging metals in Caenorhabditis elegans.NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans.Quantification of Glutathione in Caenorhabditis elegans.Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson's Disease.Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity.Neurodegeneration Induced by Metals in Caenorhabditis elegans.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.Modeling Parkinson's Disease in C. elegans.Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

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P2860

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

http://www.wikidata.org/entity/Q38279572

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2014 nî lūn-bûn

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Adam L Knight

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Guy A Caldwell

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Hanna Lohren

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Julia Bornhorst

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Kim A Caldwell

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Sudipta Chakraborty

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Tanja Schwerdtle

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Uwe Karst

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P2860

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

A role for alpha-synuclein in the regulation of dopamine biosynthesis

Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

Human DJ-1 and its homologs are novel glyoxalases

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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Caenorhabditis elegans

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