The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei.
about
Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-foldsCrystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobodyStructure and intrinsic disorder of the proteins of the Trypanosoma brucei editosomeDiverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma bruceiThe zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.A protein-protein interaction map of trypanosome ~20S editosomes.OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity.KREX2 is not essential for either procyclic or bloodstream form Trypanosoma brucei.The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomesUridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transferKREPB6, KREPB7, and KREPB8 are important for editing endonuclease function in Trypanosoma brucei.Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei.Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei.Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function.U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in SightDifferential functions of two editosome exoUases in Trypanosoma brucei.The Architecture of Trypanosoma brucei editosomes.Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.Kinetoplastid RNA editing involves a 3' nucleotidyl phosphatase activity.The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein.
P2860
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P2860
The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
The KREPA3 zinc finger motifs ...... urvival of Trypanosoma brucei.
@en
type
label
The KREPA3 zinc finger motifs ...... urvival of Trypanosoma brucei.
@en
prefLabel
The KREPA3 zinc finger motifs ...... urvival of Trypanosoma brucei.
@en
P2093
P2860
P921
P356
P1476
The KREPA3 zinc finger motifs ...... urvival of Trypanosoma brucei.
@en
P2093
Kenneth D Stuart
Nancy Lewis Ernst
Xuemin Guo
P2860
P304
P356
10.1128/MCB.01115-08
P407
P577
2008-09-15T00:00:00Z