Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1).
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Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificityPECAM-1, a key player in neuroinflammationThe carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cellsCollaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targetingPECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesisAggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31)Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31Increased endothelial cell expression of platelet-endothelial cell adhesion molecule-1 during hyperoxic lung injury.PECAM-1: conflicts of interest in inflammation.Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactionsDifferential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases.PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in CisAlternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature.PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesisPECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells.An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling.Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis.The biology of PECAM-1.Role of high endothelial postcapillary venules and selected adhesion molecules in periodontal diseases: a review.PECAM-1: regulator of endothelial junctional integrity.Animal lectins.Interaction of CD31 with a heterophilic counterreceptor involved in downregulation of human T cell responses.Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype.Influence of PECAM-1 ligand interactions on PECAM-1-dependent cell motility and filopodia extensionThrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis.Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms.Expression pattern of alternatively spliced PECAM-1 isoforms in hematopoietic cells and platelets.Tissue specific expression of alternatively spliced murine PECAM-1 isoforms.Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity.Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras.Involvement of endothelial PECAM-1/CD31 in angiogenesis.Activity-dependent regulation of alternative splicing patterns in the rat brain.CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
P2860
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P2860
Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1).
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Alternative splicing of a spec ...... adhesion molecule-1 (PECAM-1).
@en
type
label
Alternative splicing of a spec ...... adhesion molecule-1 (PECAM-1).
@en
prefLabel
Alternative splicing of a spec ...... adhesion molecule-1 (PECAM-1).
@en
P2093
P2860
P356
P1476
Alternative splicing of a spec ...... adhesion molecule-1 (PECAM-1).
@en
P2093
P2860
P304
23672-23680
P356
10.1074/JBC.270.40.23672
P407
P577
1995-10-01T00:00:00Z