Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
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Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosisLocus control regionsRegulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and betaHepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisMassively parallel functional dissection of mammalian enhancers in vivo.STAT1 interacts with RXRα to upregulate ApoCII gene expression in macrophages.Hepatocyte nuclear factor 4α and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virusDifferential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes.Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein ClDefective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.In vivo footprinting analysis of the hepatic control region of the human apolipoprotein E/C-I/C-IV/C-II gene locus.Adeno-Associated Virus Gene Therapy for Liver Disease.Hepatic control elements promote long-term expression of human coagulation factor IX gene in hydrodynamically transfected mice.Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster.Construction of minicircle DNA vectors capable of correcting familial hypercholesterolemia phenotype in a LDLR-deficient mouse model.Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distDuplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue.A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different biTwo hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster.
P2860
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P2860
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
description
1995 nî lūn-bûn
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1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
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1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
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1995年學術文章
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name
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
@en
type
label
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
@en
prefLabel
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
@en
P2093
P2860
P356
P1476
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
@en
P2093
P2860
P304
22577-22585
P356
10.1074/JBC.270.38.22577
P407
P577
1995-09-01T00:00:00Z