Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis.
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Structural Characterization of Myotoxic Ecarpholin S From Echis carinatus VenomStructural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A₂ classStructural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA2 InhibitionSnake Venom Cytotoxins, Phospholipase A2s, and Zn(2+)-dependent Metalloproteinases: Mechanisms of Action and Pharmacological RelevanceStructural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein classNeurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo.Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids.Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating proteinMembrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper.Crystallization and preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with rosmarinic acid.A Lys49 phospholipase A2, isolated from Bothrops asper snake venom, induces lipid droplet formation in macrophages which depends on distinct signaling pathways and the C-terminal region.Crystallization and preliminary X-ray diffraction analysis of three myotoxic phospholipases A2 from Bothrops brazili venom.Crystallization and preliminary X-ray diffraction analysis of a Lys49-phospholipase A2 complexed with caffeic acid, a molecule with inhibitory properties against snake venomsDistinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2.Topology of the substrate-binding site of a Lys49-phospholipase A2 influences Ca2+-independent membrane-damaging activity.Crystallization and preliminary X-ray diffraction analysis of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom.A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change.Identification of vascular endothelial growth factor receptor-binding protein in the venom of eastern cottonmouth. A new role of snake venom myotoxic Lys49-phospholipase A2.Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development.
P2860
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P2860
Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Active-site mutagenesis of a L ...... s in the absence of catalysis.
@en
type
label
Active-site mutagenesis of a L ...... s in the absence of catalysis.
@en
prefLabel
Active-site mutagenesis of a L ...... s in the absence of catalysis.
@en
P2093
P2860
P1433
P1476
Active-site mutagenesis of a L ...... s in the absence of catalysis.
@en
P2093
Arthur H C de Oliveira
Juliana M Sá
Lucimara Chioato
Richard J Ward
Roberto Ruller
P2860
P356
10.1042/0264-6021:3620089
P407
P577
2002-02-01T00:00:00Z