Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos.
about
Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation.Blastocyst-Derived Stem Cell Populations under Stress: Impact of Nutrition and Metabolism on Stem Cell Potency Loss and Miscarriage.Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress.Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.CoQ10 increases mitochondrial mass and polarization, ATP and Oct4 potency levels, and bovine oocyte MII during IVM while decreasing AMPK activity and oocyte death.Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.
P2860
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P2860
Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Commonly used fertility drugs, ...... in cultured mammalian embryos.
@en
type
label
Commonly used fertility drugs, ...... in cultured mammalian embryos.
@en
prefLabel
Commonly used fertility drugs, ...... in cultured mammalian embryos.
@en
P2093
P2860
P1476
Commonly used fertility drugs, ...... in cultured mammalian embryos.
@en
P2093
Alan Bolnick
Alexandra M Shamir
Brian Kilburn
Daniel A Rappolee
Elizabeth E Puscheck
Mindie Howard
Mohammed Abdulhasan
Paul Andresen
P2860
P2888
P304
P356
10.1007/S10815-016-0735-Z
P577
2016-05-26T00:00:00Z
P6179
1004182566