Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
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The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activationp75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.Treatment of vestibular schwannoma cells with ErbB inhibitorsBAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro.Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas.Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival.Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesisGrowth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.Role of Merlin/NF2 inactivation in tumor biology.Neurofibromatosis-2 and spinal cord ependymomas: Report of two cases and review of the literature.Gene expression, signal transduction pathways and functional networks associated with growth of sporadic vestibular schwannomas.Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas.Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.
P2860
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P2860
Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
@en
type
label
Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
@en
prefLabel
Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
@en
P2093
P1476
Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
@en
P2093
Abraham Jacob
Bradley Welling
Brian A Neff
Long-Sheng Chang
Shyra Miller
Tina X Lee
P356
10.1097/MAO.0B013E31816021F7
P577
2008-01-01T00:00:00Z