Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
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Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanismsUCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditionsPersistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine productionTranscriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell functionThe mitochondrial uncoupling proteinsSirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsGhrelin's second life: from appetite stimulator to glucose regulatorReactive oxygen species in health and diseaseTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failureRedox homeostasis in pancreatic β cellsLoss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activityMitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searchingOverexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.New Insights for Oxidative Stress and Diabetes MellitusChronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunctionMitochondrial regulation of β-cell function: maintaining the momentum for insulin releaseUncoupling protein 2 gene polymorphisms in association with overweight and obesity susceptibility: A meta-analysisObesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic StrategiesMitochondrial proton and electron leaksGene loss, thermogenesis, and the origin of birdsPhysiological and pathological roles of mitochondrial SLC25 carriersBrown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistanceRedox regulation of mitochondrial functionMitochondrial hormesis and diabetic complicationsSoluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistanceFoxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releaseThe basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen speciesHeterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 proteinDynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cellsProliferation and differentiation of osteoblasts from the mandible of osteoporotic ratsAdenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretionGlucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study.Calcium release channel RyR2 regulates insulin release and glucose homeostasisGenomic structure and expression of uncoupling protein 2 genes in rainbow trout (Oncorhynchus mykiss)Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgeryInsulin signaling regulates mitochondrial function in pancreatic beta-cells
P2860
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P2860
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Uncoupling protein-2 negativel ...... function, and type 2 diabetes.
@en
type
label
Uncoupling protein-2 negativel ...... function, and type 2 diabetes.
@en
prefLabel
Uncoupling protein-2 negativel ...... function, and type 2 diabetes.
@en
P2093
P50
P921
P1433
P1476
Uncoupling protein-2 negativel ...... sfunction, and type 2 diabetes
@en
P2093
B B Lowell
P304
P356
10.1016/S0092-8674(01)00378-6
P407
P577
2001-06-01T00:00:00Z