about
Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNPA short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophyRescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulationSMN in spinal muscular atrophy and snRNP biogenesisRNA and diseaseAn antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicingTIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.Drug discovery and development for spinal muscular atrophy: lessons from screening approaches and future challenges for clinical development.SMN-inducing compounds for the treatment of spinal muscular atrophy.Antisense oligonucleotides for the treatment of spinal muscular atrophy.A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNAAlternative splicing in spinal muscular atrophy underscores the role of an intron definition model.Bifunctional RNAs targeting the intronic splicing silencer N1 increase SMN levels and reduce disease severity in an animal model of spinal muscular atrophyThe Silent Sway of Splicing by Synonymous SubstitutionsA rare variant (c.863G>T) in exon 7 of SMN1 disrupts mRNA splicing and is responsible for spinal muscular atrophySpinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexesThe spliceosome as target for anticancer treatment.The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.Targeting RNA-splicing for SMA treatment.Progress in therapeutic antisense applications for neuromuscular disorders.Dual masking of specific negative splicing regulatory elements resulted in maximal exon 7 inclusion of SMN2 gene.Developing therapies for spinal muscular atrophy.Diverse role of survival motor neuron protein.How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophyAlternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.Phylogenetic and expression analysis of RNA-binding proteins with triple RNA recognition motifs in plants.Embracing the complexity of pre-mRNA splicing.RNA splicing. The human splicing code reveals new insights into the genetic determinants of diseaseA structured RNA in hepatitis B virus post-transcriptional regulatory element represses alternative splicing in a sequence-independent and position-dependent manner.A Multilayered Control of the Human Survival Motor Neuron Gene Expression by Alu Elements.Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Evolving concepts on human SMN pre-mRNA splicing.
@en
type
label
Evolving concepts on human SMN pre-mRNA splicing.
@en
prefLabel
Evolving concepts on human SMN pre-mRNA splicing.
@en
P356
P1433
P1476
Evolving concepts on human SMN pre-mRNA splicing
@en
P2093
Ravindra N Singh
P356
10.4161/RNA.4.1.4535
P577
2007-01-01T00:00:00Z