Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
about
Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: an NMR structural studyMal connects TLR2 to PI3Kinase activation and phagocyte polarizationRecognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activationThe structural biology of Toll-like receptorsSilica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationPathogen recognition and inflammatory signaling in innate immune defensesToll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNARadiotherapy combination opportunities leveraging immunity for the next oncology practiceMolecular Selection, Modification and Development of Therapeutic Oligonucleotide AptamersIntracellular nucleic acid sensors and autoimmunityPlasmacytoid dendritic cells and type I IFN: 50 years of convergent historyCrystal structure of the C-terminal domain of mouse TLR9Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligandsInternational Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseMyD88: a central player in innate immune signalingStructure and dynamic behavior of Toll-like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols of Plasmodium falciparumComparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesisIsolated Toll-like receptor transmembrane domains are capable of oligomerizationNucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responsesGuanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cellsMolecular Determinants of GS-9620-Dependent TLR7 ActivationAn in situ autologous tumor vaccination with combined radiation therapy and TLR9 agonist therapyThe ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.Expression analysis of turkey (Meleagris gallopavo) toll-like receptors and molecular characterization of avian specific TLR15.Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 GlucanPost-traumatic anxiety associates with failure of the innate immune receptor TLR9 to evade the pro-inflammatory NFκB pathway.A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking.A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteinsNo better time to FRET: shedding light on host pathogen interactions.Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartmentsA five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.TLR 9 activation in dendritic cells enhances salmonella killing and antigen presentation via involvement of the reactive oxygen species.Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9.Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNAG-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.Innate immune recognition of viruses and viral vectors.Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction.
P2860
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P2860
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
@en
type
label
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
@en
prefLabel
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
@en
P2093
P2860
P50
P356
P1433
P1476
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
@en
P2093
Alberto Visintin
Anjali Verma
Brian G Monks
Dionne C G Klein
Douglas T Golenbock
Eicke Latz
Marc S Lamphier
P2860
P304
P356
10.1038/NI1479
P407
P577
2007-06-17T00:00:00Z