Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.
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Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into miceThe Role of Krüppel-like Factor 4 in Renal FibrosisOsteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro.The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).Proteomic identification of 14-3-3zeta as an adapter for IGF-1 and Akt/GSK-3beta signaling and survival of renal mesangial cells.Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibitionA DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cellsStaging of biliary atresia at diagnosis by molecular profiling of the liverTransforming growth factor-beta and fibrosisSmall RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are?Human placental trophoblast as an in vitro model for tumor progression.Latent transforming growth factor β-binding protein 4 is downregulated in esophageal cancer via promoter methylation.Significant biological role of sp1 transactivation in multiple myelomaSp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts.Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation.LPS Down-Regulates Specificity Protein 1 Activity by Activating NF-κB Pathway in Endotoxemic Mice.Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesisSp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles.SP1 and UTE1 Decoy ODNs inhibit activation and proliferation of hepatic stellate cells by targeting tissue inhibitors of metalloproteinase 1.Oxidative and nitrosative stress and fibrogenic response.miR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1.MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1.Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathwaysRole of host genetics in fibrosis.Molecular basis of organ fibrosis: potential therapeutic approaches.Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstruction.Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β.Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells.Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes.Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites.Identification and characterization of the human xylosyltransferase I gene promoter region.Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis.Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain.Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells.Asporin expression is highly regulated in human chondrocytes.Inhibition of basal and transforming growth factor-beta-induced stimulation of COL1A1 transcription by the DNA intercalators, mitoxantrone and WP631, in cultured human dermal fibroblasts.Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions.Melatonin augments expression of the procollagen α1 (I) and α1 (III) genes in the infarcted heart scar of pinealectomized rats.Mithramycin reduces expression of fibro-proliferative mRNAs in human gingival fibroblasts.Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes.
P2860
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P2860
Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Blocking sp1 transcription fac ...... treatment of tissue fibrosis.
@en
type
label
Blocking sp1 transcription fac ...... treatment of tissue fibrosis.
@en
prefLabel
Blocking sp1 transcription fac ...... treatment of tissue fibrosis.
@en
P2093
P1476
Blocking sp1 transcription fac ...... treatment of tissue fibrosis.
@en
P2093
Verrecchia F
P304
P356
10.1046/J.1523-1747.2001.01326.X
P407
P577
2001-05-01T00:00:00Z
P6179
1004525757