Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. - Wikidata - awgldk - TriplyDB

Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo.

Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo.

http://www.wikidata.org/entity/Q38311242

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TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns Neonatal host defense against Staphylococcal infections Immune vulnerability of infants to tuberculosis Ontogeny of early life immunity Immune response to vaccine adjuvants during the first year of life A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses The host immune dynamics of pneumococcal colonization: implications for novel vaccine development The role of myeloid-derived suppressor cells in immune ontogeny Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant New approaches to preventing, diagnosing, and treating neonatal sepsis.Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.Induction and termination of inflammatory signaling in group B streptococcal sepsis.Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.Acquisition of adult-like TLR4 and TLR9 responses during the first year of life.MicroRNA-142-3p and let-7g Negatively Regulates Augmented IL-6 Production in Neonatal Polymorphonuclear Leukocytes.Systemic stimulation of TLR2 impairs neonatal mouse brain development.Role of innate host defenses in susceptibility to early-onset neonatal sepsis.IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.Development of newborn and infant vaccines The challenge of assessing infant vaccine responses in resource-poor settings Soluble mediators regulating immunity in early life Circulating matrix metalloproteinase levels after ventricular septal defect repair in infants.Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants TLR-based immune adjuvants.LPS- and LTA-induced expression of IL-6 and TNF-α in neonatal and adult blood: role of MAPKs and NF-κB.Immune responses in neonates.Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.Developmental allometry and paediatric malaria.Neonatal innate TLR-mediated responses are distinct from those of adults.Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta).Bench-to-bedside review: Neonatal sepsis-redox processes in pathogenesis Hyper innate responses in neonates lead to increased morbidity and mortality after infection.An animal model for chorioamnionitis at term.Immune regulation of ovarian development: programming by neonatal immune challenge.Reduced frequency of a CD14+ CD16+ monocyte subset with high Toll-like receptor 4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns.Ventilator-induced lung injury. Similarity and differences between children and adults.In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

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Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo.

http://www.wikidata.org/entity/Q38311242

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Pediatric Research

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Innate immunity of the human n ...... oduction in vitro and in vivo.

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Donatella F Angelone

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Eugenie E Suter

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Leslie A Kalish

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Melissa Coughlin

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Michael R Wessels

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Ofer Levy

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Piero Valentini

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P2860

Toll-like receptor signalling

Recognition of gram-negative bacteria and endotoxin by the innate immune system.

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

Directing transition from innate to acquired immunity: defining a role for IL-6.

The two faces of IL-6 on Th1/Th2 differentiation.

Receptors and immune sensors: the complex entry path of human cytomegalovirus.

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses

Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.

Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

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1035397586

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