Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.
about
Type 2 diabetes: etiology and reversibilityThe nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicitySpecificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin releasePPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cellsPPARα in Obesity: Sex Difference and Estrogen Involvement.ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice.PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation.Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: is that a latent disadvantage?Expression of PPARalpha modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice.Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?Quantification of intrapancreatic fat in type 2 diabetes by MRI.Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes.Adaptive changes of human islets to an obesogenic environment in the mouse.Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis.Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemicsPPARs and the kidney in metabolic syndrome.Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese miceSystemic effects of white adipose tissue dysregulation and obesity-related inflammation.Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus.Mechanisms of β-cell functional adaptation to changes in workloadPharmacogenetics of posttransplant diabetes mellitus.Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity.Distinct but complementary contributions of PPAR isotypes to energy homeostasis.Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.Antidiabetic and Hypolipidemic Activities of Curculigo latifolia Fruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats.Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects.Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes.Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.Translating aetiological insight into sustainable management of type 2 diabetes.Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.Pancreatic triacylglycerol distribution in type 2 diabetes.Effect of cocoa in diabetes: the potential of the pancreas and liver as key target organs, more than an antioxidant effect?
P2860
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P2860
Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Peroxisome proliferator-activa ...... lipotoxicity in human islets.
@en
type
label
Peroxisome proliferator-activa ...... lipotoxicity in human islets.
@en
prefLabel
Peroxisome proliferator-activa ...... lipotoxicity in human islets.
@en
P2093
P50
P356
P1433
P1476
Peroxisome proliferator-activa ...... s lipotoxicity in human islets
@en
P2093
Brigitte Vandewalle
Catherine Fiévet
Folkert Kuipers
Frédéric Percevault
Gérard Torpier
Jean-Charles Fruchart
Julie Kerr-Conte
Maaike Oosterveer
P304
P356
10.2337/DB06-0016
P407
P577
2006-06-01T00:00:00Z