The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells.
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Lin28 and let-7 in cell metabolism and cancerHemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in KidneyThe Dimerization State of the Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2)Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition.miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer.Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.HMGB1 in health and disease.Regulation of microRNA function in somatic stem cell proliferation and differentiationEngineering Hematopoietic Stem Cells: Lessons from Development.Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells.Hmga2 regulates self-renewal of retinal progenitors.Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans.Maternal high-fat diet and obesity compromise fetal hematopoiesis.MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLCHuman cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placentaMicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2).A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions.Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancyErythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer.Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground stateThe pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts.Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer.Transcription factor networks directing the development, function, and evolution of innate lymphoid effectorsBiogenesis and regulation of the let-7 miRNAs and their functional implications.MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28BRNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cellsLoss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosisDevelopmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapyDevelopmental changes in hematopoietic stem cell properties.Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells.
P2860
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P2860
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The Lin28b-let-7-Hmga2 axis de ...... tal haematopoietic stem cells.
@en
type
label
The Lin28b-let-7-Hmga2 axis de ...... tal haematopoietic stem cells.
@en
prefLabel
The Lin28b-let-7-Hmga2 axis de ...... tal haematopoietic stem cells.
@en
P2093
P356
P1433
P1476
The Lin28b-let-7-Hmga2 axis de ...... tal haematopoietic stem cells.
@en
P2093
Christopher Day
Claudia Benz
Connie J Eaves
David G Kent
David J H F Knapp
David Q Treloar
Florian Kuchenbauer
Heidi Mader
Keegan Rowe
Michael R Copley
P2888
P304
P356
10.1038/NCB2783
P577
2013-06-30T00:00:00Z
P6179
1013332482