about
Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseasesThree-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic propertiesComparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1A Possible Role for Metallic Ions in the Carbohydrate Cluster Recognition Displayed by a Lewis Y Specific AntibodyStructural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling ComplexesAntimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosisAllosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivityStructure activity relationship of dendrimer microbicides with dual action antiviral activityInsights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.An FcgammaRIIa-binding peptide that mimics the interaction between FcgammaRIIa and IgG.Molecular Simulations of Carbohydrates with a Fucose-Binding Burkholderia ambifaria Lectin Suggest Modulation by Surface Residues Outside the Fucose-Binding Pocket.Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses.Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmissionFree Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form.Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping.A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection.An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.Crystal structures of human antibodies: a detailed and unfinished tapestry of immunoglobulin gene products.Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1).Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1.Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissuesHIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismAlternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms.MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.Carbohydrates in CyberspaceRole for the terminal clasp of HIV-1 gp41 glycoprotein in the initiation of membrane fusionA computational approach for exploring carbohydrate recognition by lectins in innate immunityThree-dimensional structures of carbohydrate determinants of Lewis system antigens: implications for effective antibody targeting of cancer.Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancersA common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutationsCross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor.Acquisition of Functional Antibodies That Block the Binding of Erythrocyte-Binding Antigen 175 and Protection Against Plasmodium falciparum Malaria in ChildrenNon-canonical peptides bound to MHC.Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications.
P50
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P50
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հետազոտող
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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Paul A. Ramsland
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0000-0002-2107-2738