The linker region between the helicase and primase domains of the bacteriophage T7 gene 4 protein is critical for hexamer formation.
about
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stallingMechanism and evolution of DNA primasesModular architecture of the hexameric human mitochondrial DNA helicaseHexameric RSF1010 helicase RepA: the structural and functional importance of single amino acid residuesImpact of macromolecular crowding on DNA replication.The Autographa californica nuclear polyhedrosis virus p143 gene encodes a DNA helicaseIdentification of domains of the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin.A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factorMechanism of sequence-specific template binding by the DNA primase of bacteriophage T7The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNADisease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.Molecular basis for recognition of nucleoside triphosphate by gene 4 helicase of bacteriophage T7.Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7.Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.DNA primase acts as a molecular brake in DNA replication.Mechanisms of helicases.The Arabidopsis At1g30680 gene encodes a homologue to the phage T7 gp4 protein that has both DNA primase and DNA helicase activities.The hepatitis C virus NS3 protein: a model RNA helicase and potential drug targetA ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase proteinBypass of a nick by the replisome of bacteriophage T7Physical analysis of recombinant forms of the human mitochondrial DNA helicaseExpression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.Molecular interactions in the priming complex of bacteriophage T7.Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication.Understanding helicases as a means of virus control.Single-molecule studies of complex systems: the replisome.Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7.Primase-based whole genome amplification.Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells.Discrete interactions between bacteriophage T7 primase-helicase and DNA polymerase drive the formation of a priming complex containing two copies of DNA polymerase.The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling.An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities.Loading strategies of ring-shaped nucleic acid translocases and helicases.Primer initiation and extension by T7 DNA primaseInteraction of bacteriophage T7 gene 4 primase with its template recognition site.Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase.Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein.Replisome Dynamics during Chromosome Duplication.One-way traffic of a viral motor channel for double-stranded DNA translocationThe N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities.
P2860
Q24310134-5FF6A364-E22B-4D33-8ABB-69F4F59DD526Q24612068-F4388366-3851-4FA2-9DD2-1169430E83E2Q24648359-BF3C25BB-CEA3-4C96-89CA-4682D2003F4AQ27642302-52C547E5-4C5F-4790-9D6F-832F504FEB7FQ30428470-D65FE5E6-6DDF-4F03-A285-EB915F1055F6Q33787137-13703176-F794-47EC-9D8B-F423906B1DD4Q33809498-A4C1C356-6A94-4E13-B2EB-89BBAEB2191BQ33935984-6BD9C66A-4625-4683-85E8-037E79C5C067Q34020264-C07D0B85-6C44-4C41-9B98-04CFB6635A49Q34107139-79A5E169-8891-4693-9968-326C74716A87Q34144719-A497D1E6-C56A-4AEF-92E6-3679444FC734Q34181409-2B43513B-AAB5-45E4-893D-A1D7A61AD6B7Q34189392-74B63C32-FA7F-486B-B3E5-3013CEAE0EE1Q34405895-398E5E17-904B-45EF-B453-6205A5DCE79EQ34490702-89588387-49E1-428A-8364-AB15C2CFDD39Q34521150-2658B7BD-28ED-4AEE-BC98-C7BD0F636132Q34604541-519CAF7E-274D-4DB5-9CA9-79881E7143C5Q34607601-FA952C66-8E9F-4D32-A861-F78D98AB82EBQ35114392-77FE81A1-5477-4FA0-BB7C-05FAC8BADEC3Q35150239-8CF4D02E-3856-431C-93DA-15FBBEC45EFCQ35851875-EDA53ACC-AA78-46A1-A66E-9039752C23BFQ35865328-BCC98F59-781F-4119-B4C5-986A00EC1BEDQ36066299-A1FD8B02-DCE9-4417-8C24-D934A1FD4B9FQ36298398-DB9755A6-516A-4F03-AF7E-96E8A0A3E0BEQ36447325-BFAE6DEC-160B-4F3F-AE4A-06B402F1CE6EQ36716466-D86A2611-9817-4E1C-835A-8A06F9B9A852Q36752413-01B15729-772A-4681-9EB5-E62A1FE44972Q36798701-38FA1EC6-D6FA-413B-A049-0CC91DFE502EQ36860866-9D9B9548-8F50-4E31-A33B-346199801B38Q37112474-7E44C3BF-F571-40D1-A8FA-8B7804E5100CQ37357506-0E689B5E-EE88-4712-A505-7A9E05CDAB52Q37358209-D4264A55-6110-4475-8087-73163318ED1FQ38216120-A62ECD2C-7EE9-4601-A19F-7C07DCE8A2F7Q38313902-C61BF81F-3A87-403D-BE89-393AB89DE2A9Q38317856-8993607C-9170-47D9-BDF9-513D6677FFE8Q38325861-663A73F6-4407-47B4-977E-6DC8BFB33E78Q38343188-2EA5127E-AA6E-4EDF-843E-7889D2F1DD00Q38601246-79D7A1BC-998D-45C2-9603-F90128A2584FQ42142685-FEB599E7-BCAC-4E1A-8FAE-A414697B383AQ43042722-C56CAC86-CFC4-49B6-AF95-DE5CD1E6FD4E
P2860
The linker region between the helicase and primase domains of the bacteriophage T7 gene 4 protein is critical for hexamer formation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The linker region between the ...... ritical for hexamer formation.
@en
type
label
The linker region between the ...... ritical for hexamer formation.
@en
prefLabel
The linker region between the ...... ritical for hexamer formation.
@en
P2093
P2860
P356
P1476
The linker region between the ...... ritical for hexamer formation.
@en
P2093
P2860
P304
30303-30309
P356
10.1074/JBC.274.42.30303
P407
P577
1999-10-01T00:00:00Z