Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.
about
Mitochondria in the diabetic heartCardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium ChannelsNew Molecular Insights of Insulin in Diabetic CardiomyopathyReactive oxygen species, nutrition, hypoxia and diseases: Problems solved?Lean heart: Role of leptin in cardiac hypertrophy and metabolismMitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathyHow exercise may amend metabolic disturbances in diabetic cardiomyopathyCardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapiesImmunoproteasomes: structure, function, and antigen presentationDiabetic Cardiomyopathy: Does the Type of Diabetes Matter?Animal Models in Cardiovascular Research: Hypertension and AtherosclerosisMitochondrial morphology in metabolic diseasesMitochondrial dysfunction in diabetic cardiomyopathyProtective mechanisms of mitochondria and heart function in diabetesMitochondrial dynamics in diabetic cardiomyopathySubstrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout heartsA PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetesInsulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study.Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice.Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) miceDiabetic cardiomyopathy: pathophysiology and clinical featuresTranscriptome alteration in the diabetic heart by rosiglitazone: implications for cardiovascular mortality.Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation.Lipotoxicity in the heart.Obesity and preclinical changes of cardiac geometry and function.Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation.High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injuryReduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study.Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulationDiabetic cardiomyopathy, causes and effects.Cardiac remodeling in obesity.Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in miceImprovement of mechanical heart function by trimetazidine in db/db mice.An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice.The critical role of Astragalus polysaccharides for the improvement of PPARα [ correction of PPRAα]-mediated lipotoxicity in diabetic cardiomyopathyCorruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress.
P2860
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P2860
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Reduced cardiac efficiency and ...... nsulin resistance and obesity.
@en
type
label
Reduced cardiac efficiency and ...... nsulin resistance and obesity.
@en
prefLabel
Reduced cardiac efficiency and ...... nsulin resistance and obesity.
@en
P2093
P356
P1433
P1476
Reduced cardiac efficiency and ...... insulin resistance and obesity
@en
P2093
Gopa Chakrabarti
Jonathan Buchanan
Matthew W Roberts
Pradip K Mazumder
Robert C Cooksey
Sheldon E Litwin
Ui Jeong Yun
P304
P356
10.1210/EN.2005-0938
P407
P50
P577
2005-09-01T00:00:00Z