about
Gelatinase B/MMP-9 in Tumour Pathogenesis and ProgressionConstitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype.Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma.Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity.TrkAIII promotes microtubule nucleation and assembly at the centrosome in SH-SY5Y neuroblastoma cells, contributing to an undifferentiated anaplastic phenotype.Nifedipine in the treatment of Raynaud's phenomenon in patients with systemic sclerosis.Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain.The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability.The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.TrkAIII. A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance.Thioredoxin inhibits microvascular endothelial capillary tubule formation.bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells.Transforming growth factor-beta1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity.Retinoic acid-enhanced invasion through reconstituted basement membrane by human SK-N-SH neuroblastoma cells involves membrane-associated tissue-type plasminogen activator.Transcriptional regulation of intercellular adhesion molecule 1 by phorbol ester in human neuroblastoma cell line SK-N-SH involves jun- and fos-containing activator protein 1 site binding complex(es).Mode of formation of synovial villiRas levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues.NGF sensitizes TrkA SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis.The effects of levan on the acute inflammatory response.Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells.All-trans-retinoic acid induces nuclear factor kappaB activation and matrix metalloproteinase-9 expression and enhances basement membrane invasivity of differentiation-resistant human SK-N-BE 9N neuroblastoma Cells.Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site.Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate.Activation of MMP-2 by human GCT23 giant cell tumour cells induced by osteopontin, bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent.Increased matrix metalloproteinase-9 secretion in short-term tissue cultures of prostatic tumor cells.The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.Mapping of receptor binding sites on IL-1 beta by reconstruction of IL-1ra-like domainsIncreased chemiluminescence of polymorphonuclear leucocytes from patients with progressive systemic sclerosisThe transition from acute to chronic inflammationEffect of a lymphocyte-derived pro-inflammatory factor on carrageenan pleurisy in the ratThe role of plasma factors in the adherence of leucocytes to vascular endothelial cellsStudies into the mode of action of non-steroidal anti-inflammatory drugs using a model of facsimile synoviumIdentification of the 72-kDa (MMP-2) and 92-kDa (MMP-9) gelatinase/type IV collagenase in preparations of laminin and MatrigelThioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasionTranscriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elTrkAIII expression in the thymusA pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Andrew Reay Mackay
@ast
Andrew Reay Mackay
@en
Andrew Reay Mackay
@es
Andrew Reay Mackay
@nl
type
label
Andrew Reay Mackay
@ast
Andrew Reay Mackay
@en
Andrew Reay Mackay
@es
Andrew Reay Mackay
@nl
prefLabel
Andrew Reay Mackay
@ast
Andrew Reay Mackay
@en
Andrew Reay Mackay
@es
Andrew Reay Mackay
@nl
P106
P1153
7202401947
P21
P31
P496
0000-0001-7096-3759