about
BH3 domains other than Bim and Bid can directly activate Bax/BakDirect activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisPUMA couples the nuclear and cytoplasmic proapoptotic function of p53PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisIdentification and characterization of a novel rat ov-serpin family member, trespinBH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectlyMitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology.Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor modelsPivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3.B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.p53 and metabolism: Inside the TIGAR.The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.The BCL-2 family reunion.p53's believe it or not: lessons on transcription-independent death.Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3.GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosisDissecting p53-dependent apoptosis.Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationBAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins.BAK/BAX activation and cytochrome c release assays using isolated mitochondria.Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteinsHow do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formationSurvival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers.Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis.Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.Getting away with murder: how does the BCL-2 family of proteins kill with immunity?How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition.Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance.Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens.Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatmentBcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells.Immune biomarkers are more accurate in prediction of survival in ulcerated than in non-ulcerated primary melanomas.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jerry E. Chipuk
@ast
Jerry E. Chipuk
@en
Jerry E. Chipuk
@es
Jerry E. Chipuk
@sl
type
label
Jerry E. Chipuk
@ast
Jerry E. Chipuk
@en
Jerry E. Chipuk
@es
Jerry E. Chipuk
@sl
prefLabel
Jerry E. Chipuk
@ast
Jerry E. Chipuk
@en
Jerry E. Chipuk
@es
Jerry E. Chipuk
@sl
P106
P1153
6507931034
P21
P31
P496
0000-0002-1337-842X