about
Cdc73 Subunit of Paf1 Complex Contains C-terminal Ras-like Domain That Promotes Association of Paf1 Complex with ChromatinHrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.Degradation-mediated protein quality control in the nucleus.A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability.Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO.The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubilityDynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic StressCotrafficking of SV2 and synaptotagmin at the synapse.Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.A yeast model for polyalanine-expansion aggregation and toxicityExposed hydrophobicity is a key determinant of nuclear quality control degradation.A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction SitesEndoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.Substrate recognition in nuclear protein quality control degradation is governed by exposed hydrophobicity that correlates with aggregation and insolubility.Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane proteinRewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitinationHow a disordered ubiquitin ligase maintains order in nuclear protein homeostasisCellular maintenance of nuclear protein homeostasisProtein quality control in the nucleus.Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.The cellular location of Prevotella ruminicola beta-1,4-D-endoglucanase and its occurrence in other strains of ruminal bacteria.The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control.A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes.A 'distributed degron' allows regulated entry into the ER degradation pathway.Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.The recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex.A Prevotella ruminicola B(1)4 operon encoding extracellular polysaccharide hydrolases.An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast.Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.Mapping the Landscape of a Eukaryotic Degronome.Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressorThe effect of carbohydrates on the expression of the Prevotella ruminicola 1,4-beta-D-endoglucanaseDigging for Buried Amino Acids Unearths New Protein Quality Control TreasureProtein Quality Control Degradation in the NucleusFrom Precise Slicing to General SHREDding: The Ubiquitin Ligase Ubr1 Roqs as a Multipurpose Protein TerminatorIntegrated Proteogenomic Approach for Identifying Degradation Motifs in Eukaryotic CellsThe extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate
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description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Richard G Gardner
@ast
Richard G Gardner
@en
Richard G Gardner
@es
Richard G Gardner
@nl
Richard G Gardner
@sl
type
label
Richard G Gardner
@ast
Richard G Gardner
@en
Richard G Gardner
@es
Richard G Gardner
@nl
Richard G Gardner
@sl
prefLabel
Richard G Gardner
@ast
Richard G Gardner
@en
Richard G Gardner
@es
Richard G Gardner
@nl
Richard G Gardner
@sl
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0000-0003-2162-6275