Identification of the region of alpha-catenin that plays an essential role in cadherin-mediated cell adhesion.
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Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent proteinα-Catenin-mediated cadherin clustering couples cadherin and actin dynamics.Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturationp120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activityBinding to F-actin guides cadherin cluster assembly, stability, and movement.Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation.Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras.Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42.α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strengthHigh correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia.Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent.Direct interaction of the C-terminal domain of alpha-catenin and F-actin is necessary for stabilized cell-cell adhesion.alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex.Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesionMonomeric α-catenin links cadherin to the actin cytoskeleton.E-cadherin cytoplasmic domain inhibits cell surface localization of endogenous cadherins and fusion of C2C12 myoblastsWnt/beta-catenin signaling down-regulates N-acetylglucosaminyltransferase III expression: the implications of two mutually exclusive pathways for regulation.Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis.Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells.Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin.Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis.
P2860
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P2860
Identification of the region of alpha-catenin that plays an essential role in cadherin-mediated cell adhesion.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Identification of the region o ...... dherin-mediated cell adhesion.
@en
type
label
Identification of the region o ...... dherin-mediated cell adhesion.
@en
prefLabel
Identification of the region o ...... dherin-mediated cell adhesion.
@en
P2860
P356
P1476
Identification of the region o ...... dherin-mediated cell adhesion.
@en
P2093
P2860
P304
29524-29529
P356
10.1074/JBC.273.45.29524
P407
P577
1998-11-01T00:00:00Z