The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes.
about
Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic developmentPax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancerPOU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 elementThe LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcriptionActivation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3.Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor gamma and thiazolidinedione oral antidiabetic drugsRegulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Islet-specific proteins interact with the insulin-response element of the glucagon gene.Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6.Characterization of a novel calcium response element in the glucagon gene.Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein.Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.Characterization of a novel protein kinase C response element in the glucagon gene.Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity.Glucagon gene G3 enhancer: evidence that activity depends on combination of an islet-specific factor and a winged helix protein.Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements.Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element.Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES)
P2860
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P2860
The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
The pancreatic islet-specific ...... atostatin and insulin-I genes.
@en
type
label
The pancreatic islet-specific ...... atostatin and insulin-I genes.
@en
prefLabel
The pancreatic islet-specific ...... atostatin and insulin-I genes.
@en
P2093
P356
P1476
The pancreatic islet-specific ...... atostatin and insulin-I genes.
@en
P2093
P304
P356
10.1210/MEND-5-10-1457
P577
1991-10-01T00:00:00Z