An alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A.
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Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosisCrystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysisA sensitive fluorescence-based assay for monitoring GM2 ganglioside hydrolysis in live patient cells and their lysatesIn cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 gangliosideProtease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis modelIntroduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease.Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.
P2860
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P2860
An alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A.
description
2004 nî lūn-bûn
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2004年の論文
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name
An alpha-subunit loop structur ...... ding by beta-hexosaminidase A.
@en
type
label
An alpha-subunit loop structur ...... ding by beta-hexosaminidase A.
@en
prefLabel
An alpha-subunit loop structur ...... ding by beta-hexosaminidase A.
@en
P2093
P2860
P1476
An alpha-subunit loop structur ...... ding by beta-hexosaminidase A.
@en
P2093
Don Mahuran
John Callahan
Maryam Zarghooni
Michael Tropak
Scott Bukovac
P2860
P304
P356
10.1016/J.BBRC.2004.09.159
P407
P577
2004-11-01T00:00:00Z