Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
about
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterningNotch Signaling in Pancreatic DevelopmentOpposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegansNotch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis.Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.Astragaloside attenuates myocardial injury in a rat model of acute myocardial infarction by upregulating hypoxia inducible factor‑1α and Notch1/Jagged1 signaling.Mammary gland morphological and gene expression changes underlying pregnancy protection of breast cancer tumorigenesisNemo-like kinase regulates postnatal skeletal homeostasis.Nemo-like kinase is critical for p53 stabilization and function in response to DNA damageNotch signaling in pediatric soft tissue sarcomasβ-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells.Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activityPhosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling.Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.NLK functions to maintain proliferation and stemness of NSCLC and is a target of metforminIn vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastomaWakayama Symposium: Notch-FoxL2-α-SMA axis in eyelid levator muscle development and congenital blepharophimosis.NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.Expression of Nemo-like kinase was increased and negatively correlated with the expression of TCF4 in lung cancers.Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinaseLentivirus-based RNA silencing of Nemo-like kinase (NLK) inhibits the CAL 27 human adenosquamos carcinoma cells proliferation and blocks G0/G1 phase to S phaseNLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling.S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development.Targeting Notch to target cancer stem cells.Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling.C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependent signallingPhosphorylation of Suppressor of Hairless impedes its DNA-binding activity.Homodimerization of Nemo-like kinase is essential for activation and nuclear localizationNLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells.Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis.Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.Notch Signaling in Development, Tissue Homeostasis, and Disease.An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.Src kinase phosphorylates Notch1 to inhibit MAML binding
P2860
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P2860
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Nemo-like kinase suppresses No ...... ctive transcriptional complex.
@en
type
label
Nemo-like kinase suppresses No ...... ctive transcriptional complex.
@en
prefLabel
Nemo-like kinase suppresses No ...... ctive transcriptional complex.
@en
P2093
P356
P1433
P1476
Nemo-like kinase suppresses No ...... ctive transcriptional complex.
@en
P2093
Kenichi Harigaya
Kunihiro Matsumoto
Maho Suzuki
Miho Isoda
Motoo Kitagawa
Motoyuki Itoh
Shizuka Ishitani
Tohru Ishitani
Tomoko Hirao
P2860
P2888
P304
P356
10.1038/NCB2028
P577
2010-01-31T00:00:00Z
P6179
1052411554