Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region.
about
Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumorsGarlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.PharmGKB summary: very important pharmacogene information for CYP1A2.Role of CAR and PXR in xenobiotic sensing and metabolism.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Signaling control of the constitutive androstane receptor (CAR)Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.Regulation of gene expression by CAR: an update.Establishment of a stable aryl hydrocarbon receptor-responsive HepG2 cell lineCytogenetic evaluation and the association with polymorphisms of the CPY1A1 and NR1I3 genes in individuals exposed to BTEX.Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat HepatocytesRegulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells.The effect of CYP1A2 gene polymorphism on the metabolism of theophylline.
P2860
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P2860
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Constitutive androstane recept ...... ent in the 5'-flanking region.
@en
type
label
Constitutive androstane recept ...... ent in the 5'-flanking region.
@en
prefLabel
Constitutive androstane recept ...... ent in the 5'-flanking region.
@en
P2093
P1476
Constitutive androstane recept ...... ent in the 5'-flanking region.
@en
P2093
Kouichi Yoshinari
Noriaki Yoda
Takayoshi Toriyabe
Yasushi Yamazoe
P304
P356
10.1016/J.BCP.2009.08.008
P407
P577
2009-08-12T00:00:00Z